Notably, it is important to rationally interpret TFE3 rearrangements in the context of morphology, as TFE3 rearrangements are also seen in other tumors such as alveolar soft tissue sarcomas, Xp11.2 translocation-associated renal cell carcinomas, and perivascular epithelioid cell tumors. Here, TFE3 is linked to neoplasm with perivascular epithelioid cell differentiation.