Notably, it is important to rationally interpret TFE3 rearrangements in the context of morphology, as TFE3 rearrangements are also seen in other tumors such as alveolar soft tissue sarcomas, Xp11.2 translocation-associated renal cell carcinomas, and perivascular epithelioid cell tumors. The gene discussed is TFE3; the disease is renal cell carcinoma.