ALKBH5 and thyroid cancer: However, recent research has demonstrated that ALKBH5, an RNA demethylase homologous to AlkB, can impede the progression of thyroid cancer by inducing ferroptosis in thyroid cancer cells via the TIAM1-Nrf2/Heme Oxygenase 1 (HO-1) axis, as evidenced by both in vitro and in vivo studies.