In terms of speech problems, the improvement effect of high DAI-AGR is more significant in males (HR=0.500, 95%CI:0.259-0.966), primary and below (HR=0.292, 95%CI:0.113-0.752), smoking (HR=0.462, 95%CI:0.233-0.916), drinking (HR=0.320, 95%CI:0.139-0.734), stage I/II (HR=0.355, 95%CI:0.139-0.904), high levels ALT (HR=0.406, 95%CI:0.165-0.997), and low levels AST (HR=0.330, 95%CI:0.121-0.903) ESCC patients (Figure 1). Here, GPT is linked to esophageal squamous cell carcinoma.