Electronic databases, including PubMed, Scopus, and Web of Science, were systematically searched using keywords and Medical Subject Headings terms such as “efpeglenatide,” “type 2 diabetes,” “obesity,” “GLP-1 receptor agonists,” “glycemic control,” “HbA1c,” “body weight,” and “safety profile.” This evidence concerns the gene GLP1R and type 2 diabetes mellitus.