NOS3 and cardiovascular disorder: Dysfunction and uncoupling of eNOS are associated with cardiovascular diseases (CVD) (Janaszak-Jasiecka et al., 2023; Heitzer et al., 2000a; Munzel et al., 2005), and increased eNOS expression and reversal of eNOS uncoupling in experimental models improves vascular function (Li et al., 2006).