NOS2 and myocardial infarction: Of note, in the model of myocardial infarction, iNOS expression is upregulated, and oral sepiapterin administration inhibits nitrotyrosine formation and increases in nitrite and nitrate in wildtype, eNOS−/−, and nNOS−/− mice, but not iNOS−/− mice; these effects are associated with prevention of cardiac remodeling and dysfunction (Shimazu et al., 2011).