NOS3 and ischemia: AVE9488 is another eNOS transcription enhancer that has been shown to increase eNOS expression and activity, reverse eNOS uncoupling, protect against ischemia-reperfusion cardiac injury, and improve post-infarct function (Sasaki et al., 2006; Wohlfart et al., 2008; Frantz et al., 2009; Fraccarollo et al., 2008).