CX3CL1 and Alzheimer disease: Inflammation plays an integral role in AD, and chemokine CX3CL1 (C-X3-C motif ligand 1, aka Fractalkine), emerging as a key molecule linking inflammatory and neuroprotective mechanisms within the central nervous system, play a special role in the development of AD (Zhang et al., 2021; Bivona et al., 2023; Pawelec et al., 2020) and aging (Pawelec et al., 2020; Mecca et al., 2018).