Hepatic DEN metabolism produces O6-ethyl deoxyguanosine and O4- and O6-ethyl deoxythymidine, which are mutagenic and carcinogenic.16,17 The effect of analyzed phytoconstituents of KM on low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) and β-catenin signaling pathway, which play a role in hepatocellular carcinoma (HCC), was also studiedin silico. This evidence concerns the gene LRP6 and hepatocellular carcinoma.