ADORA2B and liver dysplastic nodule: For example, the A2B adenosine receptor antagonist MRS1754 has been shown to reduce the expression of chemokine chemoattractants and adhesion genes in glomerular monocytes/macrophages, leading to alterations in the M1/M2 macrophage ratio, enhanced macrophage-myofibroblast transition, and reduced fibrosis and inflammation in DN (53).