TLR7 and systemic lupus erythematosus: Additionally, estrogen stimulation of CD11b+ monocytes derived from C57BL/6 female mice culminated in the enhanced expression of Unc93b1, a molecular chaperone required for TLR7 activity (97) and splenocytes from lupus-prone female mice expressed higher levels of Unc93b1 as compared to C57BL/6 controls (98).