Our results recapitulate the latest data discussed about theinconsistent alteration of Ucp1 gene levels supportingthe idea that canonical thermogenesis is not occurring in this context.Moreover, it has to be taken into account that ALS-related mouse models arecharacterized by a high heterogeneity of symptoms and pathological features thatcan introduce confounding factors, mostly in regard of the disease staging andanimal life expectancy that varies across models, target genes and geneticmutations. Here, UCP1 is linked to amyotrophic lateral sclerosis.