Severe COVID-19 cases are often associated with elevated IL-6 and IL-10 levels and T lymphocytopenia, but the understanding of T-CD4 and T-CD8 functions in SARS-CoV-2 patients is limited.34 The relationship between the host immune status, including humoral and cellular responses, and disease outcomes remains partially evaluated with inconclusive results. This evidence concerns the gene CD4 and COVID-19.