[145], in their study on ischemic stroke, showed that RIPK1 enhances the vascular endothelial growth factor D (VEGF‐D)/VEGF receptor VEGFR‐3 signaling pathways and contributes to astrogliosis and glial scar formation, and RIPK3 and MLKL are also involved in ischemia‐induced reactive astrogliosis in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)‐induced astrocytic injury model. The gene discussed is VEGFD; the disease is ischemia.