In mice with spinal cord injury (SCI), high mobility group box1 (HMGB1) in DAMPs induces pro‐inflammatory microglia activation via the receptor for advanced glycation endproducts (RAGE)‐NF‐κB pathway, and inhibition of HMGB1 or RAGE significantly reduces neuronal loss and demyelination [115]. The gene discussed is HMGB1; the disease is spinal cord injury.