NTRK1 and glioblastoma: Signalling pathways related to the receptor tyrosine kinase MET [54] and ECM organisation [55] are also found enriched by genes epigenetically downregulated in GIC as compared to iNSC (Additional File 1: Fig.S9a) as well as deregulation of keratinisation, previously described in a glioblastoma context [56].