Whilst it has not been described in glioblastoma to date, our data suggests that, in GIC, gene body region of UBE2D1 is in a poised state which could allow the cancer cells to response quicker to cellular stress such as hypoxia by decreasing HIF1-apha degradation, promoting angiogenesis and tumour maintenance in a hypoxic environment. The gene discussed is UBE2D1; the disease is neoplasm.