PSMD3 and cancer: We found loss of H3K27ac at genes related to Proteasome subunits type A, B, C and D (PSM), in particular PSMD1 and PSMD3 (Additional File 1: Fig.S4b and Additional File 3: table S1), which have been shown to act as tumour suppressors and inhibit Wnt signalling [28] in other cancers, though not yet described in glioblastoma.