ITGβ4, a transmembrane adhesion molecule composed of hemidesmosomes, plays a vital role in various cancer cell biology functions [48].Plectin and ITGβ4 have been shown to interact to link with other cytoskeletal networks, thereby contributing to maintain cellular structural organization [27], and previous studies have demonstrated that ITGβ4 and PLEC in promoting prostate cancer progression [30, 49], however, their involvement in OC remains elusive. This evidence concerns the gene PLEC and cancer.