Non-LNM), and the results showed that tumor progression and immune regulation-related pathways such as Agiogenesis, PI3K AKT MTOR signaling, Inflammatory response, IL2 STAT5 signaling, Interferon α response, Interferon γ response, and TNFα pathway were significantly upregulated in the lymph node metastasis group (Fig. 7A). This evidence concerns the gene TNF and neoplasm.