In the musculoskeletal context of rheumatoid arthritis and osteoarthritis, the anti-inflammatory effects of α-MSH on synovial fibroblasts and chondrocytes have been well described, but only a few studies have been carried out regarding the impact of the melanocortin system on osteoblasts and bone or bone regeneration [15–17, 31]. Here, STAMBP is linked to rheumatoid arthritis.