Their infiltration into the tumour may also be limited in ME patients due to the lack of upregulation of key chemokine receptors upon entry into the tissue, including CXCR4 and CXCR5, which have been shown to be important for control of B and T cell trafficking into tissues and play central roles in orchestrating the adaptive cell functions54. The gene discussed is CXCR4; the disease is neoplasm.