We subdivided patients into CD8+ high vs. CD8+ low, and CD163+ high vs. CD163+ low groups, which highlighted a subset of patients with relatively high CD8+ T cell infiltration and low CD163+ macrophage infiltration (equivalent to the AE patient group), and a subset with relatively low CD8+ T cell infiltration and high CD163+ macrophage infiltration (equivalent to the ME patient group). This evidence concerns the gene CD163 and acrodermatitis enteropathica.