We also explored the relationship between CREB5 expression and the clinicopathological features of HCC, finding that high CREB5 expression was correlated with tumor size (Fig. 2J) and degree of differentiation (Fig. 2K), but not with age, sex, history of hepatitis/cirrhosis, or AFP level (Supplementary Table 1). This evidence concerns the gene CREB5 and hepatitis A virus infection.