BRD4 and non-small cell lung carcinoma: In non-small cell lung cancer, SE promote TGFβ-induced EMT by enhancing the expression of EMT-related transcription factors, while a BRD4-specific inhibitor JQ1 can inhibit SE-driven transcription of ETS2, HNF4A, JUNB, and other genes, resulting in the obstruction of EMT process [30].