TP53 and hepatocellular carcinoma: Some agents were found to induce apoptosis in HCC cells by targeting other members of the apoptosis pathway, such as scutellarein targeting Fas/FasL,506 Garciniaxanthone I,507 Compound 19b and lycorine targeting Cyt-C.508,509 P53 also transcriptionally regulates the expressions of cyclins and cyclin-dependent kinases (CDKs), which lead to cell cycle arrest.