Non-canonical Notch signaling can be started by a non-canonical ligand, or in the absence of a ligand, or may not need cleavage of the Notch receptor, or interactions with other cytoplasmic or cytosolic effectors.406,407 In addition, Notch signaling crosstalks with others like NF-κB, mTORC, TGF-β, AKT, Wnt, or Hippo to modulate target gene transcriptions.408–412 Notch pathway can function as both carcinogens and tumor suppressors depending on the context of cancers and cell populations. Here, TGFB1 is linked to cancer.