EGFR is expressed in over 60% of HCC patients, and is positively correlated with poor differentiation, high proliferative activity, advanced stage, intrahepatic metastasis, and poorer PFS.46–49 EGFR exhibits high expression levels in HCC cell lines and tissues, and furthermore, up-regulated EGFR expression in circulating tumor microemboli maintains stability and distal metastasis of suspended HCC cells by activating Ras/MAPK pathway.50 The high EGFR-related pathway signaling in HCC may be related to alterations in its regulatory factors and overexpressed ligands.20,51,52. This evidence concerns the gene EGFR and hepatocellular carcinoma.