Kinds of inhibitors showed growth suppressive effect in HCC, including PORCN inhibitors (LGK-974, ETC-159),331 fungal derivatives (PKF115-854 and CGP0449090),332,333 TNKS inhibitor XAV939.334 Interfering RNA– or antisense RNA–based therapy constitutes another method to suppress the Wnt/β-catenin pathway, showing suppressive effect to HCC in vitro335,336 and in mouse models.307,337. This evidence concerns the gene TNKS and hepatocellular carcinoma.