Additionally, CD4+IL-17A+TH17 cells contribute to NAFLD/NASH-induced HCC by promoting neutrophil recruitment and accumulation of fatty acids.602 IgA+ plasma cells with high expression of PD-L1 and IL-10 accumulate in NASH, inhibiting CTL activation and promoting HCC. This evidence concerns the gene CD4 and metabolic dysfunction-associated steatohepatitis.