The gain-of-function mutations of CTNNB1 occurred in HCCs with HCV (28%),298,299 alcohol (42%) 70 and non-cirrhotic liver in the absence of common risk factors of HCC.300 While AXIN1 is more frequently mutated in HBV-related HCCs (18%) than in HCV-related or non-viral HCCs (14% and 8%, respectively).299 Mutations of Wnt/β-catenin were more often identified to be associated with nonproliferation subgroups of HCC but also found in proliferation group.300. Here, CTNNB1 is linked to hepatocellular carcinoma.