PIK3C3 is required to the cancer stem cells (CSCs) growth and activity.231 Hepatic mTORC2 facilitates hepatosteatosis via de novo fatty acid and lipid synthesis in HCC.232 While long-term inhibition of mTORC1 promotes HCC development through promoting IL-6/STAT3 pathway in a murine model of obesity,233 which indicates the complex function of mTORC1 in HCC might relates to the etiology. The gene discussed is PIK3C3; the disease is hepatocellular carcinoma.