Histone methyltransferases and demethylases, such as EZH2, EHMT2, SETDB1 and SETD2 were found to be correlated with the clinical characteristics of human HCC tissues.450 EZH2-mediated H3K27me3 signifies a major oncogenic chromatin modification and is involved in sorafenib resistance and HCC growth.451–453 Other specific histone modifications are also dysregulated in HCC. The gene discussed is SETDB1; the disease is hepatocellular carcinoma.