In B cells, PD-1 activation recruits SHP-2 to dephosphorylate BCR pathway molecules, inhibiting PI3K, ERK, and PLCγ2 pathways, disrupting calcium signaling and inhibiting B cell growth.537 PD-1 overexpression in B cells induces T cell dysfunction through an IL-10-dependent pathway, promoting tumor progression. This evidence concerns the gene IL10 and neoplasm.