Based on the accumulated knowledge from existing studies, we focused on reviewing and discussing the roles of eight RTKs classes including VEGF receptor (VEGFR), Epidermal growth factor receptor (EGFR), c-Met, platelet-derived growth factor (PDGFR), fibroblast growth factor receptor (FGFR), insulin-like growth factor receptor (IGFR), KIT, RET (Rearranged during transfection) and their downstream pathways including MAPK pathway, Phosphatidylinositol 3-kinase (PI3K) pathway and JAK-STAT pathway in biological behaviors of HCC as well as their therapeutic implications. This evidence concerns the gene EGFR and hepatocellular carcinoma.