Based on the levels of SUMF2 protein expression in BLCA tissues, the samples were categorized into low- and high-expression groups, as shown in Fig. 2B. We found that SUMF2 expression levels in BLCA tissues were significantly associated with grade (P < 0.001), T status (P = 0.011), and stage (P = 0.006) (Fig. 2C and Table 2). This evidence concerns the gene SUMF2 and bladder transitional cell carcinoma.