The similarity between IMD and higher-grade glioma is not only evident in their their metabolomic acylcarnitine signature, by also in terms of enzymology; with expression in clinical samples of higher levels of ACSS1/2 and ACSS2, as well as transporters responsible for fluxing FAs into the cytoplasm and mitochondria compartments, MCT1 and SLC25A2. The gene discussed is ACSS1; the disease is glioma.