We confirmed that CLDN6 expression was significantly higher in EC than in normal esophageal tissue, that [89Zr]Zr-DFO-IMAB027 exhibited visual target specificity and sustained accumulation in CLDN6-positive EC models, and that [177Lu]Lu-DOTA-IMAB027 demonstrated continuous tumor suppression with controllable safety. The gene discussed is CLDN6; the disease is neoplasm.