Elevated low-density lipoprotein (LDL) cholesterol, decreased levels of apoA-1 and elevated levels of apoB are associated with increased risk of aortic stenosis.21 22 Statin treatment has not been shown to be effective in reducing this risk.23 24 However, a secondary analysis of the SEAS study, evaluating simvastatin and ezetimibe combined, showed a 60% reduced risk for valve replacement among patients with mild aortic stenosis and LDL >4 mmol/L.25 The gene discussed is APOB; the disease is aortic stenosis.