Different from the role of HSPG2 in AML cells,49 this study focused on the HSPG2 level on BM EPCs in AML‐CR patients after chemotherapy, we found that HSPG2 could promote the normal haematopoiesis‐supporting ability of BM EPCs without affecting their leukaemia cell‐supporting ability via a series of in vitro coculture assays. Here, HSPG2 is linked to leukemia.