Lastly, 48 h exposure of hypoxia has been shown to increase both mRNA and protein levels of L-type amino acid transporter 1, a branched-chain amino acid (BCAA) transporter, and branched-chain aminotransferase 1 (BCAT1), which catalyzes the first step in BCAA catabolism, in glioblastoma cells. The gene discussed is BCAT1; the disease is glioblastoma.