Although CDKN2A expression was positively associated with the infiltration of tumor-killing CD8 T-cells, it was also positively correlated with immunosuppressive cells such as regulatory T-cells (Treg) and immunoinhibiting factors such as PD1 and LAG3, indicating that higher CDKN2A expression has the potential to induce immunosuppressive TME and T-cell allergy, thereby leading to the malignant features and poor prognosis of patients with THCA. This evidence concerns the gene LAG3 and neoplasm.