In fact, based on this mechanism, various agents with the ability to influence copper metabolism such as Disulfiram and Sanchoishi have been used in cancer treatment.28, 29, 30 Notably, copper can also promote angiogenesis and subsequent tumor growth, by stimulating pro-angiogenic signals.31, 32 In addition, copper can activate the BRAF signaling pathway in cancers, thereby promoting tumor cell proliferation and migration.32 The gene discussed is BRAF; the disease is neoplasm.