Moreover, Tukey’s HSD test revealed the highest level of AT8 and 6e10 appeared in the YDem group, indicating a possible combined effect of ApoE4 and dementia in exacerbating effect in Tau hyperphosphorylation and Aβ aggregation in AD patients as described in previous studies [11,20,30,33,40]. The gene discussed is MAPT; the disease is dementia.