TARDBP and amyotrophic lateral sclerosis: Measurement of total TDP‐43 and pTDP‐43 in plasma have been challenging and limited by the sensitivity of ELISA‐based assays, variability of TDP‐43 and pTDP‐43 levels within control and ALS/FTLD populations, and the insolubility of TDP‐43 aggregates in biofluids.27