Elevation of plasma phosphorylated Tau181 (pTau181), phosphorylated Tau 217 (pTau217) and phosphorylated Tau (pTau231) are proposed as biomarkers of Alzheimer's Disease pathology,10 and recently pTau181 was also discovered to be elevated in ALS plasma.11, 12. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.