In the svgp12 cells, effects on FDX1 expression were not detected at the same drug concentrations used for the GBM cells (10 μM CuCl2 and 40 nM Elesclomol), though higher drug concentrations (10 μM CuCl2 and 100 nM Elesclomol) effectively induced cuproptosis, as indicated by decreased FDX1 expression (Fig 7A). Here, FDX1 is linked to glioblastoma.