Points in OB-CMI score, including preeclampsia with severe features or eclampsia, preeclampsia/gestational/chronic hypertension, congestive heart failure, pulmonary hypertension, ischemic heart disease/cardiac arrhythmia, congenital heart and/or valvular disease, placental abruption, autoimmune disease/lupus, HIV/AIDS, sickle cell disease/bleeding disorder/coagulopathy/anticoagulation, epilepsy/cerebrovascular accident/neuromuscular disorder, chronic kidney disease, asthma, diabetes requiring insulin, maternal age, substance use disorder, alcohol abuse, and BMI (18 risk factors). The gene discussed is INS; the disease is alcohol abuse.