Our findings revealed that we had missed at least 10% of central CH cases based on the new RI, including a case of MPHD that mean while had presented with severe hypoglycemia due to combined growth hormone and ACTH deficiency (M R Garrelfs, N Zwaveling-Soonawala and A S P van Trotsenburg, unpublished observations). Here, GH1 is linked to cyclic hematopoiesis.