RHOT1 and Parkinson disease: Herein, we dissected the importance and potential pathways of Miro1 in PD pathogenesis by focusing on patient-specific p.R272Q Miro1 mutant models and the in vivo p.R285Q orthologue Miro1 mutation, which is located in the N-terminal EF-hand domain of the protein and is responsible for calcium sensing.4