In vitro, transcriptomic analyses in Miro1 p.R272Q mutant versus healthy or isogenic controls showed a mutation-specific deregulation on PD pathways, which are also known to be altered in sporadic and familial PD, such as LRRK2 and Tau, oxidative stress, iron homeostasis and apoptosis.44-46 For example, UBL5 (ubiquitin-related) and FTL (iron-related) have previously been linked to Miro1-mediated mitophagy regulation4 and to an iron-calcium-Miro axis,47 respectively. Here, LRRK2 is linked to Parkinson disease.