RHOT1 and Parkinson disease: It is composed of a C-terminal transmembrane domain, which binds to the outer mitochondrial membrane, and two EF-hand calcium-binding domains flanked by two GTPase domains.3 Miro1 plays a fundamental role in regulating mitochondrial dynamics, calcium homeostasis and mitophagy.4 A pathological stabilization of physiological Miro1, in which its degradation induced by mitochondrial depolarization is impaired, was observed in fibroblasts5 and induced pluripotent stem cell (iPSC)-derived neurons6 from sporadic and monogenic PD patients.