Of relevance, with HSP47 being a specific chaperone for fibrillar collagen, the same therapeutic approach could be applied to several other conditions in which collagen synthesis is impaired, either genetically or acquired due to environmental factors, such as epidermolysis bullosa (69), Ehlers-Danlos syndrome (15), chondrodysplasia (70, 71), UV exposure (72), and smoking (73–75). Here, SERPINH1 is linked to Ehlers-Danlos syndrome.