A notable feature of t(11;14) MM is the elevated expression of the anti-apoptotic protein B-cell lymphoma 2 (BCL-2) in clonal plasma cells, whereas the proapoptotic proteins myeloid cell leukemia-1 (MCL-1) and BCL-XL are expressed at lower levels, rendering the cells more sensitive to BCL-2 inhibitors [32]. Here, PROS1 is linked to Miyoshi myopathy.