MALAT-1 is upregulated in some types of uterine cancers, and studies have suggested that it may act as a biomarker for distinguishing between proliferative and secretory phases of endometrial cancer as expression patterns for MALAT-1 was similar in both ESS tumor cells and normal stromal cells during proliferation phase but in the secretory phase it was substantially lower. This evidence concerns the gene MALAT1 and endometrial cancer.