Through the control of E-cadherin and vimentin expression, upregulated Sprouty RTK signaling antagonist 4-intronic transcript 1 (SPRY4-IT1)in NSCLC tumor tissues has been found to be a predictor for poor prognosis of NSCLC by promoting EMT (Hu et al. 2016). The gene discussed is SPRY4; the disease is neoplasm.