This is linked to cell adhesion and proliferation, such as epidermal growth factor receptor (EGFR), Metastasis Associated with Colon Cancer 1 (MACC1), β-catenin, and Extracellular signal-regulated kinase 1 and 2 (ERK1/2) (Wang et al. 2016a, b). This evidence concerns the gene MAPK3 and colonic neoplasm.