HMOX1 and ischemia: Daily administration of 200 mg/kg/day metformin concurrently with 10 mg/kg L-NAME, 0.1 mg/kg CORM-A1, 3 mg/ kg NaHS or 1mg/kg RAPA i.p. for 6 successive days before induction of ischemia and promptly at the onset of reperfusion to rats significantly reduced the hepatic nitrite level (Fig. 4A) and produced a significant increase in the hepatic HO-1 (Fig. 4B) and H2S (Fig. 4C) levels as compared to animals treated similarly with metformin only.