Concurrent administration of 200 mg/kg/day metformin with 0.1 mg/kg/day CORM-A1 i.p. for 6 successive days before induction of ischemia and promptly at the onset of reperfusion to rats elevated eNOS (Fig. 7), HO-1 (Fig. 9), and CSE (Fig. 10) protein expressions in the liver tissue. This evidence concerns the gene NOS3 and ischemia.