This study explores the mechanisms of YFJDT using bioinformatics, xenograft models, and A549 cells, demonstrating that YFJDT downregulates HIF1A, promotes ferroptosis, and inhibits epithelial‐mesenchymal transition (EMT) and vasculogenic mimicry (VM), suggesting novel therapeutic strategies for lung cancer. The gene discussed is HIF1A; the disease is lung carcinoma.