TBX2 and melanoma: Furthermore, TBX2 is overexpressed in a diverse range of cancers, including melanomas, sarcomas such as malignant peripheral nerve sheath tumours and rhabdomyosarcomas (RMS), and carcinomas of the breast, ovaries, stomach, pancreas, lung, prostate, colorectal, oesophagus, head and neck, and brain Figure 4.