Von Willebrand Factor (vWF) is involved in coagulation, and in SCD, vWF levels are reported to be elevated due to ongoing haemolysis and endothelial dysfunction; increased vWF levels have also recently been found associated with VOCs and acute chest syndrome (Sins et al., 2017; Shi et al., 2022; Vital and Lam, 2023). Here, VWF is linked to endothelial dysfunction.