For instance, ApoM, a subsidiary lipoprotein particle of HDL‐C, can interact with SIP and trigger the sphingosine kinase 1 (Sphk1)/SIP signaling pathway, whose activation of the downstream IL‐6/STAT3/Akt pathway is implicated in CRC carcinogenesis [51]. This evidence concerns the gene STAT3 and colorectal carcinoma.