As expected, the depletion of MNX1, via siRNAs or clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein 9 (CRISPR/Cas9) system, decreased PD‐L1 expression at both mRNA and protein levels in KYSE150 ESCC cells (Figure2a–c and Figure S1d in Supporting Information). Here, CD274 is linked to esophageal squamous cell carcinoma.