MNX1 was originally found to be expressed in lymphoid and pancreatic tissues.[26] It was later identified as an important developmental gene involved in pancreatic and motor neuronal differentiation.[27, 28, 29] Increasing evidence indicates that MNX1 is overexpressed in multiple types of human cancers and contributes to cancer progression.[30, 31, 32, 33, 34, 35, 36, 37] Here, we demonstrated that MNX1, in addition to being an oncogene, also plays a crucial role in tumor immune escape, promoting tumor progression in both immune‐dependent and non‐immune‐dependent ways. Here, MNX1 is linked to cancer.