Importantly, the depletion of MNX1 downregulated, while the ectopic expression of MNX1 upregulated PD‐L1 expression at both mRNA and protein levels in multiple cancer cell lines, which was due to stabilization of PD‐L1 mRNA rather than activation of transcription in ESCC cells. Here, MNX1 is linked to esophageal squamous cell carcinoma.