Comparing pre‐and post‐NAC samples of luminal BC, we observed a significant increase of CD3 + CD8 + FOXP3‐ lymphocytes in the post‐NAC samples, while in the TNBC subtype we observed significantly higher levels of both CD3 + CD8 + FOXP3‐ and CD3 + CD8‐FOXP3‐ lymphocytes in the post‐NAC samples. This evidence concerns the gene CD8A and breast cancer.