CYP2E1 and Cirrhosis: Its potential substrates have been shown to be metabolized by porcine CYP2B.[88] CYP2E may be involved in the formation of highly activated toxic or carcinogenic metabolites.[88] There is 75% sequence homology of CYP2E between human and porcine.[88] Alcohol, high‐fat diets and stress could activate the CYP2E‐mediated metabolism and regulate the processes of gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.[88, 94]