Taken together, the molecular mechanism of which lncRNA‐MEG3 attenuates apoptosis by regulating the interaction of p‐Anxa2 and p‐AKT in mitochondria can provide theoretical support for the application of recombinant human Annexin A2 (rA2) in clinical practice to solve the problem of poor prognosis in CIRI patients with DM. The gene discussed is MEG3; the disease is diabetes mellitus.