The TRL domain may serve to link the Map-Ebp50-ezrin-actin complex with myosin IIA to cause actin contractility and contribute to the leakage of solutes across the TJ barrier in EPEC infections as myosin IIA is an important regulator of actin contractility and opening of the TJ barrier (Zihni et al., 2016). This evidence concerns the gene NHERF1 and infection.