He presented at the age of four with recurrent bony pains requiring multiple hospital admissions (Table 1). His first hospital admission was at the age of four when he presented with right knee pain. Workup showed elevated C-reactive protein (CRP) of 26.45 mg/L (normal reference range 0-12 mg/L), elevated erythrocyte sedimentation rate (ESR) of 26 mm/hr (normal reference range 0.20-10 mm/hr), and mild anemia (hemoglobin 10.1; normal reference range 12.5-16.1 g/dL). The gene discussed is CRP; the disease is anemia.