CD4 and Kaposi's sarcoma: Our patient was initially diagnosed with IRIS based on: 1) proximity of symptoms to ART initiation (less than three months); 2) fulfillment of two out of three minor criteria for KS-IRIS (two-fold increase in CD4 T-cell count after ART initiation and elevated HHV-8 antibodies); and 3) KS progression [16] as evidenced by the patient’s new hepatic lesions on CT and ultrasound (Figure 6) and worsening pulmonary nodules on chest X-ray (Figure 7).