The patient’s lack of constitutional symptoms between hospitalizations, absence of significant lymphadenopathy and splenomegaly, and CD4 count in the low 100s (rather than greater than 200 cells/uL as typically seen in KS-MCD) made KICS the more likely diagnosis [8, 15]. Our patient did not undergo lymph node biopsy because treatment is the same for both KICS and KS-MCD due to similar disease pathophysiology [8]. The gene discussed is CD4; the disease is Splenomegaly.