For the males, as the quartiles of SPISE increased, the age, duration of diabetes, HDL-c showed a gradual increased, while the proportion of smokers, BMI, VFA, SFA, SBP, DBP, TC, LDL-c, TG, TG/HDL-c, HbA1c, FPG, ALT, AST, GGT, UA, UACR, Hb, HOMA-IR and the incidence of NAFLD exhibited a gradual decreased (all P < 0.05). Here, GSTM1 is linked to metabolic dysfunction-associated steatotic liver disease.