In cisplatin-induced AKI (CI-AKI) models that are both in vivo and in vitro, renal damage and apoptosis have been shown to be aggravated by the activation of the NLRP3 inflammasome and the ensuing generation of IL-1β and IL-18 (Shen et al., 2016; Lin et al., 2019). This evidence concerns the gene IL18 and acute kidney injury.